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In contrast to the CV outcomes trials with GLP-1RAs, those with DPP-4 inhibitors demonstrated consistent non-inferiority in both the primary composite outcome and individual components compared to placebo, and even showed some unexpected increases in risk of hospitalization for HF, acute pancreatitis, and hypoglycemia [31,32,33,34]
Glutathione is a tripeptide composed of glutamic acid, cysteine, and glycine
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Substantial evidence has been provided that IIS is an evolutionarily conserved pathway that regulates lifespan across many species like flies, worms, and mice [36]
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